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Research
Research

2009

Novel Ube3a Isoform and Angelman Syndrome

Isoforms
Mouse Model
UBE3A
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$99,425

At the DNA level, UBE3A represents a single region of DNA molecules but when UBE3A makes its proteins multiple different proteins appear and these are termed isoforms. In this project, Dr. Jiang is evaluating some of the shorter protein isoforms that have previously been less studied than the longer ones. It is hoped that an analysis of these isoforms in the AS mouse model will lead to additional understanding about the repertoire of cellular mechanisms that UBE3A can direct.

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The mission of Angelman Syndrome Foundation is to advance the awareness and treatment of Angelman syndrome through education and information, research and support for individuals with Angelman syndrome, their families and other concerned parties. We exist to give all of them a reason to smile, with the ultimate goal of finding a cure.

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