What is AS?
- - Genetic Mechanisms of Angelman Syndrome
  - Normal 15 Chromosome
  - We each have two number 15 chromosomes, one inherited from our mother (M.) and one inherited from our father (P, paternal). The Angelman syndrome gene (UBE3A) is located at chromosome 15, band q12, as depicted. In the brain, the Angelman gene is primarily expressed from the maternally inherited chromosome 15. The diagrams below illustrate the four known genetic mechanisms that cause Angelman syndrome. Continue Reading →
  - Newly Diagnosed?
  - Has someone in your family been recently diagnosed with Angelman syndrome? Fill out this simple form if you would like to receive more information on AS.
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Research
- - AS Funded Research
  - The Angelman Syndrome Foundation is the largest non-governmental funder of Angelman syndrome-specific research. It is our hope that these funded researchers, and their collaborators and peers, will bring forth new discoveries that ultimately lead to treatments and a cure.
  - Find out more.
  - Call for Proposals
  - The ASF conducts biannual calls for research proposals. Submission deadlines for review occur annually on October 15 and April 15 for one- or two-year grants.
  - See submission details
  - Families: Find out about participating in Research Studies.
  - Participating in Research.
Make an Impact
- - ASF Pop-Up Shops
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  - Personal Fundraising Pages
  - From garage sales and golf outings to climbing mountains, people honor their loved ones in many ways. Create a Personal Fundraising Page that tells your story and generate donations for ASF.
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Resources & Education
- - Resources
  - ASF Family Fund
    Family Resource Team
    International AS Resources
    Federal Resources
    State Resources
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    Professional References
    AAC & Technology
    Education Resources
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    Financial Planning
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  - Education
  - Communication Book by Dr. Calculator
    Communication Training Series
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    Angelman Syndrome A to Z
Events
- - Upcoming Events
  - Events
    
    Bank of America Chicago Marathon 2020
    
    October 11, 2020
    
    View All Events
  - ASF Events
  - Throughout the year, the Angelman Syndrome Foundation hosts, participates and receives support from events across the country.
  - Have an idea, or plan to host a local event in your area? Emailkmurphy@angelman.org with the details.
  - Fundraiser Search
AS Clinics
- - Partnership
  - The ASF has partnered with leading medical and research institutions, to found the Angelman Syndrome Clinics, a medical and psychosocial resource from birth through adulthood. Each clinic has its own unique capabilities that leverage the expertise and specialized care available from each partnering organization.
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Research

Home / Research

Angelman Syndrome Research

Research is key to improving the lives of individuals with Angelman syndrome and to finding a cure. In recent years, there have been critical discoveries that have greatly improved our understanding of Angelman syndrome.

Current Progress in Angelman Therapeutics

Here you can see current progress in finding therapeutic treatments and a possible cure for Angelman Syndrome.

angelman syndrome therapeutics — Click to open and hover to find links to more information.

Watch Dr. Art Beaudet discuss the potential for a cure for Angelman syndrome.

Clinical Trials in Angelman Syndrome

The road to clinical trial can be long. See how viable research grows into potential treatments and a clinical trial comes to life.