Investigating the Causal Role of Arc in Angelman Syndrome Pathogenesis

$170,202 (2 years)

Previous research discoveries have indicated that one of the UBE3A target proteins, Arc (activity-regulated cytoskeleton-associated protein) plays a critical role in regulating synaptic plasticity and long-term information storage in the brain.  By understanding how Arc is involved in learning and memory in the context of Angelman syndrome (AS) and how it is regulated in the Arc-dependent process, this research has the possibility to lead to development of approaches for therapeutic interventions that target the learning and memory deficits in AS.