Identification of UBE3A Ligase Substrates

$200,000 (2-year award)

Dr. Peter Howley, a long-time investigator into the role of UBE3A, has been funded by ASF to conduct state-of-the-art studies that have promise for identifying new protein targets and interacting proteins for UBE3A. This work involves using a newly established method for identifying targets (compPASS) that uses catalytically inactive forms of UBE3A proteins to identify binding and interactions with other proteins in the cell. The expectation is that this new approach will soon lead to the identification of new UBE3A protein targets, providing additional possibilities for new therapeutic strategies in AS.