$25,000 – RDCRN Training Grant
This proposal seeks to compare the yield of routine EEGs obtained as a standard in the Angelman Natural History protocol with two other types of EEG recordings to identify common EEG patterns. These patterns include ictal, inter-ictal and benign abnormal rhythms in AS. First, they will be compared to a 1 hour sample of overnight EEG recording and then compared to the entire overnight EEG recording. This analysis will provide preliminary data regarding the optimal EEG recording strategy to use in both descriptive and therapeutic trials of epilepsy in AS.  Analysis of these data will also allow us to define the correlation of the EEG abnormalities in AS to the severity of epilepsy.
The mission of Angelman Syndrome Foundation is to advance the awareness and treatment of Angelman syndrome through education and information, research and support for individuals with Angelman syndrome, their families and other concerned parties. We exist to give all of them a reason to smile, with the ultimate goal of finding a cure.