Association of Sleep and Behavior in Children with Angelman Syndrome

$25,000 – RDCRN Training Grant

This proposal seeks to compare the yield of routine EEGs obtained as a standard in the Angelman Natural History protocol with two other types of EEG recordings to identify common EEG patterns. These patterns include ictal, inter-ictal and benign abnormal rhythms in AS.  First, they will be compared to a 1 hour sample of overnight EEG recording and then compared to the entire overnight EEG recording. This analysis will provide preliminary data regarding the optimal EEG recording strategy to use in both descriptive and therapeutic trials of epilepsy in AS.  Analysis of these data will also allow us to define the correlation of the EEG abnormalities in AS to the severity of epilepsy.