$85,000 This scientist performed studies on Drosophila, the fruit fly, to determine how UBE3A dosage affects neuron development. The results demonstrated that synaptic connections and dendritic processes are abnormal both when the UBE3A protein is in high and in low […]
Read more
$62,200 Dr. Weeber has performed crucial genetic and therapeutic studies on the AS mouse model and was instrumental in conducting one of the first experiments that rescued many of the neurophysiological and behavioral problems of the Angelman mouse. To help […]
Read more
$80,000 The work in this grant extended our knowledge of brain regions that are affected when UBE3A is disrupted. Using the mouse model and studying the visual and brain cortex responses of each eye, this investigator and his laboratory were […]
Read more
$80,000 UBE3A function in the cell has remained elusive especially in terms of how UBE3A protein action relates to other proteins. Thus, researchers have been trying to identify “targets” (meaning proteins) that UBE3A is acting upon in order to either […]
Read more
$75,000 It is known that UBE3A is important inside brain neurons especially at their membrane surfaces where the synapse facilitates communication between neurons. It has also been recognized that other cellular problems develop when UBE3A is defective and this laboratory […]
Read more
$95,000 ASF foundation was proud to sponsor this research by Nobel Laureate Aaron Ciechanover who has been instrumental in characterizing the ubiquitin protein degradation system, a fundamental component of how neurons degrade or adjust proteins in order to function normally. […]
Read more
$76,055 Dr. Segal has significant experience in synthesizing molecules that bind to DNA and are able to regulate gene activity. ASF has provided funds to this investigator to pursue the possibilities that such agents, called artificial transcription factors, could have […]
Read more
$98,450 ASF has supported on many fronts research strategies in an attempt to increase the expression of UBE3A in the AS brain. As discussed for previous grants, it is known that in each nerve cell a UBE3A gene is repressed […]
Read more