Ronald L. Thibert, DO, MSPH Massachusetts General Hospital
2007
Low Glycemic Index Therapy (LGIT) for the Treatment of Epilepsy in Angelman Syndrome
$28,850
ASF has supported varied initiatives to improve treatment of seizures in AS and this grant aimed at exploring alternatives to the use of the very restrictive ketogenic diet. In the low glycemic diet, the extremely high lipid content of the ketogenic diet is avoided and more carbohydrates are provided, particularly ones that are more likely to be absorbed at a slower and more stable rate. The hypothesis is that this dietary strategy will allow more stable blood glucose levels and thus improve the control of seizures. This grant has enrolled individuals under 18 years of age in an ongoing clinical study that is providing data on strategies for use of the diet in AS.