23 May

Natural History Study and Drug Trial of Levodopa at Boston Children’s Hospital

Angelman syndrome (AS) is a rare, neurogenetic condition characterized by severe developmental delay, movement disorder, speech impairment (often with a complete lack of speech) and an unusually happy demeanor. Nearly every individual with AS . . .

Read full article. 

10 Mar

Loss Of Enzyme Reduces Neural Activity In Angelman Syndrome

New work from Michael Greenberg, chair of the department of neurobiology at Harvard Medical School (HMS), provides insight into the mystery by showing that the lost enzyme, Ube3A, interacts with a key neuronal protein in order to control how environmental input shapes synaptic connections. In other words, loss of Ube3A interferes with the brain’s ability to use environmental experience . . . 

See the article in Science Daily now.

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